Biochem/physiol Actions

Reversible: yes

Cell permeable: yes

Primary TargetPKR

General description

An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC₅₀ = 210 nM) and rescue PKR-dependent translation block (IC₅₀ = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Zhu, P.J., et al. 2011. Cell147, 1384.Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Physical form

A 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)